Исследование времени развития ВИЧ в СПИД
http://www.cdc.gov/mmwr/preview/mmwrhtml/00001257.htm
Current Trends Prevention of acquired immune deficiency syndrome (AIDS): Report of inter-agency recommendations. MMWR. 1983;32:101-3
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California cluster investigation and other epidemiologic findings suggest a "latent period" of several months to 2 years between exposure and recognizable clinical illness
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Время перехода ВИЧ в СПИД от нескольких месяцев, до 2 лет.
http://www.ncbi.nlm.nih.gov/pubmed/6608269
Auerbach DM et al. Cluster of cases of the acquired immune deficiency syndrome. Patients linked by sexual contact. Am J Med. 1984 Mar;76 (3):487-92
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On the basis of six pairs of patients, a mean latency period of 10.5 months (range seven to 14 months) is estimated between sexual contact and symptom onset.
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На основе шести пар пациентов, средний латентный период составил 10,5 месяца (от семи до 14 месяцев), оценивается от сексуальных контактов до появления симптомов болезни.
http://journals.lww.com/aidsonline/C...fection.1.aspx
Moss AR, Bacchetti P. Natural history of HIV infection. AIDS. 1989 Feb;3(2):55-61
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“It appears that in the absence of treatment, most infected persons will progress to AIDS, with a median time to progression of 7-10 years from infection
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7-10 лет
http://gateway.nlm.nih.gov/MeetingAb...102215425.html
Progression to AIDS and survival following an HIV and AIDS diagnosis in women in Australia. The National Working Group on HIV Infection in Women.
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Time from HIV diagnosis to AIDS ranged 0 to 8.4 years, median 5.7 years (95%CI,4.8-7.2).
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5,7 лет
http://www.bioscience.org/news/scientis/aids.htm
Mellors JW, Rinaldo Jr CR, Gupta P, White RM, Todd JA, Kingsley LA: Prognosis of HIV-1 infection predicted by the quantity of virus in plasma. Sicence 272, 1167-1170, 1996
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average time between the entry of the virus into the body and development of AIDS is 10-11 years. However, in certain individuals (about 20%), AIDS is manifested within 5 years of infection. Yet another 12% of individuals remain free of AIDS for 20 years.
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10-11 лет
http://yourtotalhealth.ivillage.com/...-hiv-aids.html
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The average time from HIV infection to death is 10-12 years.
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10-12 лет
Если я верно понимаю, на основе первых исследований доказывалась эффективность AZT в продлении времени развития СПИДа. Интересно, почему такой разброс?